Dr. Mario Online Rx

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Dr. Mario Online Rx
Dr. mario online rx.jpg
Official boxart-esque image of the game
Developer(s) Nintendo SPD
Publisher(s) Nintendo
Release date(s) Japan March 25, 2008
Europe May 20, 2008
Australia May 20, 2008
North America May 26. 2008
Platform(s) Wii
Rating(s) ESRB: ESRB E.png - Everyone
PEGI: PEGI 3.png - Ages 3+
CERO: CERO A.png - All ages
Input(s) Wii Remote
Wii Remote+Nunchuck
Wii Classic Controller
Game chronology
Previous game
Dr. Mario & Puzzle League
Next game
Dr. Mario Express
On affiliated sites
Strategy Wiki Logo.png Walkthrough
NIWA.png Dr. Mario Online Rx
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Dr. Mario Online Rx (or Dr. Mario & Germ Buster in Europe and Australia) is a WiiWare puzzle game released by Nintendo in 2008. It is the fourth installment in the Dr. Mario series.

The gameplay consists of two modes: Dr. Mario and Virus Buster. The gameplay of Dr. Mario is consistent from past entries in the series, in which the player has to line multicolored Megavitamins being thrown by Dr. Mario or the player's Mii up with similarly colored Viruses in order to destroy them. Clearing all of the Viruses clears the stage and allows the player to advance to a higher difficulty. The Flash mode involves destroying a number of flashing Viruses in order to advance. The Vs. Mode is similar to past Vs. Modes in the series; two or more players will try to clear all of their Viruses before their opponent, and chaining cleared lines drops random assorted Megavitamins on the opponent's screen. This game also features a Vs. CPU mode.

Virus/Germ Buster mode involves using the Wii Remote cursor to select and place Megavitamins to line up with viruses in a smaller playing field. Mii doctors selected from the Mii Channel are used as a gauge next to the playing field, combating a Virus stampede. If the player does well, the Miis will advance away from the playing field, but if the player does poorly, the Miis will be pushed back.

The Mii doctors' ties and pants are determined by their favorite colors. Notably, the Miis are not shaded as detailed as in the Mii Maker, and do not have a shine applied to them.


Wii series games
Tomodachi series
Swapnote series
Other Mii-centered games
Non-Mii games for the Nintendo DS
Non-Mii games for the Wii
Non-Mii games for the Nintendo 3DS
Non-Mii games for the Wii U
Non-Mii games for the Nintendo Switch
Non-Mii games for other platforms